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Mehdi Behbahani
Scientific co-worker |
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Raum 219a
Schinkelstraße 2 (Rogowski Gebäude)
52062 Aachen
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Exercises
- during winter semesters, I give the CES Mechanics I
exercises
on Mondays 15.45-16.30h in room E2 (Schinkelstr.4) and
on Thursdays 09.00-09.45h in H201 (Intzestr.3).
Field of research
Specific Research Aspects
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red blood cells
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Red blood cells account for 99% of the cells in blood and are the reason for the complex shear-thinning and viscoelastic rheological behavior of blood.
In simulations at high shear rates, however, blood can be modelled as an incompressible Newtonian fluid. Blood damage in the form of hemolysis occurs at high shear stresses and loading times. A one-dimensional comparative shear stress can be computed from the three-dimensional stress tensor.
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blood pumps
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Blood pumps are used to assist the human heart or to replace it temporarily until a donor heart for transplantation becomes available.
These life saving devices can have the size of a small AA battery and can be implanted into the human body. The Micromed DeBakey pump is especially performing and operates at 10,000 rotations per minute. The computation and analysis of blood flow in these devices is a challenging task and requires parallel computers. Typically, we use 2048 processors simultaneously to be able to receive results within one day. Appropriate boundary conditions for the problem have to be chosen and the Navier-Stokes equations solved.
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platelets
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Simulation of platelet reactions and mural thrombus growth is based on an Advection-Diffusion-Reaction approach as described by Sorensen (pdf 3.1 MB).
In his diploma thesis, Christian Waluga has implemented these equations into the existing solver. In his study thesis, Stefan Bayer designed a blood experiment for measuring mural thrombus growth and performed numerical analysis. Linda Tran and Kirstin Vonderstein have been performing experiments with this chamber and with a Taylor-Couette system. Flow in the Taylor Couette system was numerically studied in the project work by Daniel Mayer, Daniel Claessens and Halim Faouzi. Sebastian Stock implemented shear dependent wall adhesion rates into the code. Benjamin Bergmann did a numerical study of platelet reactions in the Taylor-Couette system. Anh Mai in her Bachelor Thesis describes numerical results for the flow chamber and for a stagnation point flow.
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Offers for Project-/ Bachelor-/ Master- / Diploma thesis or HiWi-Job
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Diplom/Bachelor/Master/Project thesis - General offers
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General offers for simulation of biomedical devices download proposal (pdf)
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Diplom/Bachelor/Master/Project thesis - Beating Human Heart
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Flow through the beating human heart (Durchströmung des schlagenden menschlichen Herzens) download proposal (pdf)
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Diplom/Bachelor/Master/Project thesis - Aortic Flow
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Aortic Flow during perfusion with heart-lung machine (Aortendurchströmung während Perfusion mit Herzlungenmaschine) download proposal (pdf)
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Diplom/Bachelor/Master/Project thesis - Blood Flow (Taylor vortices)
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Simulation of vortices for blood flow in a Taylor-Couette system (Simulation der wirbelbehafteten Blutströmung in einem Taylor-Couette System) download proposal (pdf)
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Diplom/Bachelor/Master/Project thesis - Blood Flow (Shear induced Blood Damage)
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Simulation of blood damage in a Couette device (Simulation der Blutschädigung in einer Couette Apparatur) download proposal (pdf)
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Diplom/Bachelor/Master/Project thesis - Blood Flow (Material Biocompatibility)
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Simulation of blood flow in a Chandler Loop (Simulation der Blutströmung in einem Chandler Loop) download proposal (pdf)
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HiWi job - Thrombosis modeling for medical devices
Diploma, study and project theses overview
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Study thesis by Holger Franz - Abschätzung der Blutschädigung mit Hilfe eines numerischen Schädigungsmodells (CFD) im Couette-System 05/08 thesis (pdf 2.5 MB)
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Diploma thesis by Christian Waluga - Numerical Simulation of Taylor Couette Flow and Modelling of Platelet Reactions 11/08 thesis (pdf 4.6 MB)
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Project thesis by Daniel Mayer, Daniel Claessens and Halim Faouzi - Numerische Simulation einer Taylor-Couette Strömung und Modellierung thrombozytärer Reaktionen 04/09 thesis (pdf 13.7 MB)
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Study thesis by Stefan Bayer - Numerische Simulation einer laminaren Blutströmung zwischen zwei parallelen Platten mit dem Schwerpunkt auf Thrombozytenaktivierung, - adhäsion und -aggregation 02/09 thesis (pdf 14.5 MB)
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Diploma thesis by Sebastian Stock - Numerische Simulation von Blutströmung und Blutschädigung für ausgewählte Testfälle 06/09 thesis (pdf 2.3 MB)
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Bachelor thesis by Anh Mai - Numerical simulation of blood flow and shear-dependant platelet adhesion
(application to parallel plate and stagnation point flow) 02/10
thesis (pdf 4.8 MB)
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Study thesis by Benjamin Bergmann (preliminary version) - Numerische Simulation thrombozytärer Reaktionen in einem Taylor-Couette System
(unter besonderer Berücksichtigung des Scherrateneinflusses) to be completed in 02/10
preliminary thesis version (pdf 3.6 MB)
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Study thesis by Tobias Levin - Development and numerical simulation of a high shear experiment (Taylor Couette system)
to be completed in 03/10
preliminary thesis version (pdf 2.0 MB)
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Diploma thesis by Stephanie Schmitz - Numerical simulation of blood flow through the human heart
to be completed in 06/10
preliminary thesis version (pdf 2.0 MB)
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Current project activities
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JARASIM project progress (step 1: numerical simulation of aortic blood flow) - activities report Mahmoud Odabai 11/09 document (pdf 6.0 MB)
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XNS-changelog (documentation of changes to xns-code for versions xns-waluga, xns-stock and xns-seweryn-01) 11/09 document (pdf 0.2 MB)
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XNS programming progress - activities report Leszek Seweryn 10/09 document (pdf 8.6 MB)
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Design of a High Shear Experiment - activities report Mehdi Behbahani 12/09 document (pdf 0.8 MB)
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Aneurysm project - activities report Mehdi Behbahani 12/09 document (pdf 0.6 MB)
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Talks
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S. Jansen, M. Behbahani, T. Kaufmann, M. Hormes, M. Behr, U. Steinseifer, T. Schmitz-Rode, upcoming:
3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques, IV International Symposium on Modelling of Physiological Flows, Sardinia, June 02-05, 2010, abstract.
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M. Behbahani, J. Nam, C. Waluga, M. Behr, M. Pasquali, K. Mottaghy, upcoming:
Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs, American Society of Artificial Organs (ASAIO), Baltimore, May 27-29, 2010, abstract.
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy, upcoming:
Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Phsiological Flow Conditions, Joint Congress of the Scandinavian and German Physiological Society, Copenhagen, March 27-30, 2010, abstract.
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy:
Modelling and Numerical Simulation of Blood Damage (Thrombosis and Hemolysis), Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010, abstract.
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy,
Numerical Blood Flow Analysis, Thrombosis Simulation and Experimental Validation, AICES Funding - Annual Report, Aachen, November 13, 2009, abstract.
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M. Behbahani, C. Waluga, B. Bergmann, S. Stock, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy,
Flow-related Thrombocyte Reactions: An Experimental and Numerical Study, Kolloquium der Physiologie, Universitätsklinikum, Aachen, November 03, 2009, announcement.
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Seweryn, L. Tran, K. Vonderstein, M. Behr, K. Mottaghy,
Simulation of Blood Damage in Technical Devices (Simulation von Blutschädigung in Technischen Geräten: Experiment, Modellbildung und Numerische Simulation), KOPF (Kompetenzplattform) Bioengineering, FH Aachen, Jülich, October 14, 2009, announcement .
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy,
Modeling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth, European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009,
abstract.
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M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy,
Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices, European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009,
abstract.
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M. Behbahani, C. Waluga, S.Arlt, M. Behr, K. Mottaghy,
Computational Analysis of Platelet Aggregation in a Taylor-Couette System, European Society of Artificial Organs (ESAO), Geneva, Switzerland, September 3-6, 2008,
abstract.
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M. Behbahani
Numerical Analysis of Blood Pumps (Análise numérica de bombas de coração),
November 06, 2007, University of Fortaleza (UNIFOR), Fortaleza Brasil, 2007.
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M. Behbahani,
Modeling and Simulation of Blood Flow in LVADs, AICES/CCES Workshop on Blood Modeling: From Cell to Network, Aachen, September 20-21, 2007.
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M. Behbahani, M. Nicolai
Interaktive Exploration von Blutströmungsprozessen in Herzpumpen, Virtual Reality Center, Aachen, November 21, 2006.
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M. Behbahani, M. Behr, D. Arora, O. Coronado, M. Pasquali,
CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction , 14th. Congress of the International Society for Rotary Blood Pumps, August 31-September 2, 2006,
abstract.
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Posters
Umbrella-2010 symposium in Jülich, Germany poster (pdf 15.6 MB)
ESB-2009 conference in Lausanne, Switzerland poster (pdf 16.5 MB)
FDA-2008 round-robin study poster (pdf 1.2 MB)
ESAO-2008 conference in Geneva, Switzerland poster (pdf 7.5 MB)
AICES-2007 blood modeling seminar poster (pdf 6.7 MB)
Publications
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T. Finocchiaro, S. Heinke, M. Behbahani, M. Lessmann, M. Laumen, U. Steinseifer, T. Schmitz-Rode, S. Leonhardt, M. Behr and K. Hameyer,
Methods of Design, Simulation, and Control for the Development of New VAD/TAH Concepts, Biomedizinische Technik/Biomedical Engineering, vol.54, issue 5, p269-282, 2009, abstract, article (pdf 0.8 MB).
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J. Spillner, R. Kopp, T. Finocchiaro, M. Behbahani, R. Roissaint, U. Steinseifer, M. Behr and R. Autschbach,
Assistierte Zirkulation: ein Überblick aus klinischer Sicht, Biomedizinische Technik/Biomedical Engineering, vol.54, issue 5, p255-268, 2009, abstract.
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M. Behbahani, M. Behr, D. Arora, O. Coronado and M. Pasquali,
A Review of Computational Fluid Dynamics Analysis of Blood Pumps,
European Journal of Applied Mathematics, vol.20, pp. 363–397, 2009, abstract, article (pdf 0.7 MB).
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M. Behbahani, M. Behr, M. Nicolai,M. Probst,
Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM, NIC-report 2008, 2008, article (pdf 2.6 MB).
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M. Behbahani, M. Nicolai, M. Probst, M. Behr,
Simulation of Blood Flow in a Ventricular Assist Device,
inSIDE Spring 2007, article (pdf 0.8 MB).
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M. Behbahani, M. Behr, C. Bischof, F.G.E. Wolf,
Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe, RWTH Themen 1/07, 2007, article (pdf 3.3 MB).
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M. Behbahani, M. Nicolai
Interaktive Exploration von Blutströmungsprozessen in Herzpumpen, VRCA Jahresbericht 2005/2006: link to full report
, Aachen, p.88-90, October 2006, article (pdf 2.7 MB).
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Presentations
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A Study of Platelet Adhesion Mechanisms inside the Taylor-Couette System, AME Tissue Engineering Aachen, 11/09 presentation (pdf 23.0 MB)
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Numerical Blood Flow Analysis, Thrombosis Simulation and Experimental Validation, AICES Aachen, 11/09 presentation (pdf 28.0 MB)
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Flow-related Thrombocyte Reactions: an Experimental and Numerical Study, Klinikum Aachen, 11/09 presentation (pdf 37.0 MB)
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Simulation of Blood Damage in Technical Devices: Experiment, Modeling, and Numerical Simulation, FH Aachen, Jülich, 10/09 presentation (pdf 30.0 MB)
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Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices, Compiegne University, France, 09/09
presentation (pdf 9.0 MB) |
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Simulation of the Beating Human Heart, JARASIM. First step: Human Aorta. Helmholtz-Institute, Aachen, 07/09 presentation (pdf 2.3 MB)
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Flowchamber Experiments, Physiology, Aachen, 06/09 presentation (pdf 40.0 MB)
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Taylor-Couette Simulation, CATS, Aachen, 12/07 presentation (pdf 3.3 MB)
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Simulations and VR at Unifor, Fortaleza, Brazil, 11/07 presentation (pdf 57.0 MB)
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Thrombosis, CATS, Aachen, 08/07 presentation (pdf 4.2 MB)
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Debakey Mesh, CATS, Aachen, 08/07 presentation (pdf 3.3 MB)
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Debakey Pump, Virtual Reality Center, Aachen, 11/06 presentation (pdf 1.8 MB)
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Debakey Pump, ISRBP Leuven, Belgium, 09/06 presentation (pdf 1.7 MB)
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Gyro Pump and SSMUM, Rice University, Texas, USA, 05/06 presentation (pdf 3.5 MB)
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Simulation pictures
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hemolyzing red blood cell in Micromed DeBakey axial blood pump
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Taylor-vortices forming in a cylindrical gap flow. Flow simulation results in good agreement with experiments performed in collaboration with the Aachen University
ECC Physiology Group headed by Prof. Mottaghy. The influence of Taylor-vortices on the behavior of platelets was experimentally examined in Sabine Körfer's PhD thesis (PDF 2.3 MB).
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shear stress distribution for turbulent flow through a Sudden Expansion at Re=6500
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axial velocity distribution for turbulent flow through a Sudden Expansion at Re=6500
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scanning electron microscopy picture of platelets and other blood cells adhering to the wall of a plastic channel. The strong adhesion and aggregation behavior was caused by activation with ADP.
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inside the GYRO centrifugal blood pump, picture taken at RWTH Virtual Reality Center
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2010-02-07 08:56 PM
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