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Mehdi Behbahani

Professor of Biomaterials at Aachen University of Applied Sciences

New in the professorial position at FH Aachen since 2011, formerly scientific co-worker at CATS
Address
Prof. Dr.-Ing. Mehdi Behbahani
Fachhochschule Aachen
Heinrich-Mussmann-Str. 1
52428 Juelich


Contact
Telefon:  +49 241 80 53727
E-Mail:  behbahani@fh-aachen.de

Teaching

  • I now give lectures in the field of Biomaterials, Engineering Materials and Fluid Dynamics.
  • Until 2011 I gave exercises in CES Mechanics I
    exercises

Field of research

  • computational fluid dynamics, especially hemodynamics
  • simulation of blood flow in medical devices, e.g., DeBakey LVAD (axial blood pump), heart valves
  • modelling of hemolysis and thrombosis in mechanical devices
  • numerical analysis of blood flow in the human circulation, e.g., left heart, coronary arteries, aorta
  • coupling between aneurysm growth and blood flow / thrombus development

Specific Research Aspects

red blood cells

Red blood cells account for 99% of the cells in blood and are the reason for the complex shear-thinning and viscoelastic rheological behavior of blood. In simulations at high shear rates, however, blood can be modelled as an incompressible Newtonian fluid. Blood damage in the form of hemolysis occurs at high shear stresses and loading times. A one-dimensional comparative shear stress can be computed from the three-dimensional stress tensor.

blood pumps

Blood pumps are used to assist the human heart or to replace it temporarily until a donor heart for transplantation becomes available. These life saving devices can have the size of a small AA battery and can be implanted into the human body. The Micromed DeBakey pump is especially performing and operates at 10,000 rotations per minute. The computation and analysis of blood flow in these devices is a challenging task and requires parallel computers. Typically, we use 2048-4096 processors simultaneously to be able to receive results within one day. Appropriate boundary conditions for the problem have to be chosen and the Navier-Stokes equations solved.

platelets

Simulation of platelet reactions and mural thrombus growth is based on an Advection-Diffusion-Reaction approach as described by Sorensen et al.. In his diploma thesis, Christian Waluga has implemented these equations into the existing solver. In his study thesis, Stefan Bayer designed a blood experiment for measuring mural thrombus growth and performed numerical analysis. Linda Tran and Kirstin Vonderstein have been performing experiments with this chamber and with a Taylor-Couette system. Flow in the Taylor Couette system was numerically studied in the project work by Daniel Mayer, Daniel Claessens and Halim Faouzi. Sebastian Stock implemented shear dependent wall adhesion rates into the code. Benjamin Bergmann did a numerical study of platelet reactions in the Taylor-Couette system. Anh Mai in her Bachelor Thesis describes numerical results for the flow chamber and for a stagnation point flow.

further research interests

Please find a summary of my current research activities and project partners in German language here Forschungsinteressen (pdf 1.3 MB) as well as teaching interests under the follwing link Lehrinteressen (pdf 0.4 MB).

Offers for Project-/ Bachelor-/ Master- / Diploma thesis or HiWi-Job

Momentarily no particular offers for Diploma/Bachelor/Master/Project thesis at RWTH

Diplom/Bachelor/Master/Project thesis - Blood Flow (Shear induced Blood Damage)

Simulation of blood damage in a Couette device (Simulation der Blutschädigung in einer Couette Apparatur)

Diplom/Bachelor/Master/Project thesis - Blood Flow (Material Biocompatibility)

Simulation of blood flow in a Chandler Loop (Simulation der Blutströmung in einem Chandler Loop)

HiWi job - Thrombosis modeling for medical devices

Thrombose Modellierung

Diploma, study and project theses overview

Study thesis by Holger Franz - Abschätzung der Blutschädigung mit Hilfe eines numerischen Schädigungsmodells (CFD) im Couette-System 05/08
Diploma thesis by Christian Waluga - Numerical Simulation of Taylor Couette Flow and Modelling of Platelet Reactions 11/08
Project thesis by Daniel Mayer, Daniel Claessens and Halim Faouzi - Numerische Simulation einer Taylor-Couette Strömung und Modellierung thrombozytärer Reaktionen 04/09
Study thesis by Stefan Bayer - Numerische Simulation einer laminaren Blutströmung zwischen zwei parallelen Platten mit dem Schwerpunkt auf Thrombozytenaktivierung, - adhäsion und -aggregation 02/09
Diploma thesis by Sebastian Stock - Numerische Simulation von Blutströmung und Blutschädigung für ausgewählte Testfälle 06/09
Bachelor thesis by Anh Mai - Numerical simulation of blood flow and shear-dependent platelet adhesion (application to parallel plate and stagnation point flow) 02/10
Study thesis by Benjamin Bergmann - Numerische Simulation thrombozytärer Reaktionen in einem Taylor-Couette System (unter besonderer Berücksichtigung des Scherrateneinflusses) 04/10
Study thesis by Tobias Levin - Development and numerical simulation of a high shear experiment (Taylor Couette system) 03/10
Diploma thesis by Stephanie Schmitz - Numerische Simulation des schlagenden menschlichen Herzens - Berechnung der Strömungsfelder in sich zeitlich verformenden Geometrien (Numerical simulation of the beating human heart - computation of flow fields in deforming geotries, 07/10
Project thesis by Florian Lubisch, Matthias Kirchhart, Thorolf Schulte and Michael Woopen - Coupled Modelling and numerical simulation of aneurysm and thrombus growth, 08/10
Project thesis by Michael Haendel and Jan Haemisch - Pulsatile flow in human blood vessels (coronary arteries and aorta), 05/11

Current project activities

JARASIM project progress (step 1: aortic blood flow) - activities report Mehdi Behbahani 10/09
XNS programming progress - activities report Leszek Seweryn 04/10
Design of a High Shear Experiment - activities report Mehdi Behbahani 12/09
Taylor-Couette experiments - activities report Kirstin Vonderstein and Linda Tran 02/10
Flow chamber experiments - activities report Kirstin Vonderstein and Paula Keschenau 04/10
Aneurysm project - activities report Mehdi Behbahani 12/09
Influence of pulsatile blood flow on the adhesion of endothelial progenitor cells to biomaterials- activities report Mahmoud Odabai 03/10
Simulation of thrombus growth in an artificial heart valve 08/10

Talks

FZ Jülich M. Behbahani, K. Mottaghy,M. Behr: Application of Thrombosis models to Complex Blood Flow Situations, XXXVIII Congress of the European Society of Artificial Organs (ESAO) and IV Biennial Congress of the International Federation on Artificial Organs (IFAO), Porto, Portugal, October 9-12, 2011.
FZ Jülich M. Behbahani, L. Tran,S. Jockenhoevel,K. Mottaghy, M. Behr: Numerical Prediction of Thrombocyte Reactions for Application to Vascular Graft Flow Congress of the European Society for Experimental Surgery (ESSR), Aachen, Germany, May 25-28, 2011abstract.
FZ Jülich M. Behbahani, M. Behr, K. Mottaghy: Numerical and experimental evaluation of platelet reactions in blood vessels, Colloquium Molekulare Medizin, Universitätsklinikum, Aachen, September 29, 2010, announcement, abstract.
FZ Jülich M. Behbahani, M. Probst, A. Mai, L. Tran, K. Vonderstein, P. Keschenau, T. Linde, U. Steinseifer, M. Behr, K. Mottaghy: The influence of high shear on thrombosis and hemolysis in artificial organs, European Society of Artificial Organs (ESAO), Skopje, Republic of Macedonia, September 8-11, 2010, abstract appeared in The International Journal of Artificial Organs, Vol.33, No.7, p.426, July 2010.
FZ Jülich S. Jansen, M. Behbahani, M. Laumen,M. Behr, T. Kaufmann, M. Hormes, T. Schmitz-Rode, U. Steinseifer: Validation of CFD with PIV and other methods, Part II, European Society of Artificial Organs (ESAO), Skopje, Republic of Macedonia, September 8-11, 2010.
FZ Jülich M. Behbahani: Vortrag zur Rheologie von Körpergewebe (Knorpel und Muskeln), Lehrvortrag, Fachhochschule Aachen, June 23, 2010.
FZ Jülich J. Nam, D. Arora, M. Behbahani, M. Probst, M. Behr, M. Pasquali, T. Schmitz-Rode: New method for computing hemolysis in complex flows, XVIth International Workshop on Numerical Methods for Non-Newtonian Fluids, Northhampton, USA, June 13-16, 2010, abstract.
FZ Jülich S. Jansen, M. Behbahani, T. Kaufmann, M. Hormes, M. Behr, U. Steinseifer, T. Schmitz-Rode: 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques, IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010, abstract.
FZ Jülich M. Behbahani, J. Nam, C. Waluga, M. Behr, M. Pasquali, K. Mottaghy Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs, American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010, abstract appeared in ASAIO Journal, Vol.56, No.2, p.85, March-April, 2010.
FZ Jülich J. Nam, D. Arora, M. Behbahani, M. Probst, B. Benkowski, M. Behr, M. Pasquali: New computational method in tensor-based hemolysis analysis for artificial heart pump, American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010, abstract appeared in ASAIO Journal, Vol.56, No.2, p.98, March-April 2010.
FZ Jülich S. Jansen, M. Behbahani, M. Laumen, T. Kaufmann, M. Hormes, T. Schmitz-Rode, M. Behr, U. Steinseifer: Investigation of Steady Flow through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo−PIV and CFD−Simulation, American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010, abstract appeared in ASAIO Journal, Vol.56, No.2, p.98, March-April 2010.
FZ Jülich M. Behbahani, A. Mai, C. Waluga, B. Bergmann, L. Tran, K. Vonderstein, M. Behr, K. Mottaghy: Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions, Joint Congress of the Scandinavian and German Physiological Society, Copenhagen, Denmark, March 27-30, 2010, abstract appeared in Acta Physiologica, Vol. 198, supplement 677, p.185, 2010.
FZ Jülich M. Behbahani, M. Probst, A. Mai, M. Behr, L. Tran, K. Vonderstein, K. Mottaghy: Numerical Prediction of Blood Damage in Biomedical Devices, Biomedica Congress, Aachen, March 17-18, 2010, abstract appeared in Biomedica Life Science Summit Proceedings, p.145.
FZ Jülich M. Probst, M. Behbahani, E. Borrmann, S. Elgeti, M. Nicolai, M. Behr: Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices, NIC (John von Naumann Institute for Computing) Symposium, Forschungszentrum Jülich, February 24-25, 2010, abstract.
FZ Jülich M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy: Modelling and Numerical Simulation of Blood Damage (Thrombosis and Hemolysis), Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010, abstract.
Klinikum M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy: Numerical Blood Flow Analysis, Thrombosis Simulation and Experimental Validation, AICES Funding - Annual Report, Aachen, November 13, 2009
Klinikum M. Behbahani, C. Waluga, B. Bergmann, S. Stock, A. Mai, L. Tran, K. Vonderstein, M. Behr, K. Mottaghy: Flow-related Thrombocyte Reactions: An Experimental and Numerical Study, Kolloquium der Physiologie, Universitätsklinikum, Aachen, November 03, 2009
FH-Aachen M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Seweryn, L. Tran, K. Vonderstein, M. Behr, K. Mottaghy: Simulation of Blood Damage in Technical Devices (Simulation von Blutschädigung in Technischen Geräten: Experiment, Modellbildung und Numerische Simulation), KOPF (Kompetenzplattform) Bioengineering, FH Aachen, Jülich, October 14, 2009, announcement .
ESB M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein , M. Behr, K. Mottaghy: Modeling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth, European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009, abstract.
ESAO-09 M. Behbahani, C. Waluga, B. Bergmann, A. Mai, L. Tran, K. Vonderstein, M. Behr, K. Mottaghy: Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices, European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009, abstract appeared in The International Journal of Artificial Organs, Vol 32, No.7, p.398, July, 2009.
ISRBP M. Behbahani, C. Waluga, S.Arlt, M. Behr, K. Mottaghy: Computational Analysis of Platelet Aggregation in a Taylor-Couette System, European Society of Artificial Organs (ESAO), Geneva, Switzerland, September 3-6, 2008, abstract appeared in The International Journal of Artificial Organs, Vol.31, No.7, p.643, July, 2008.
Talk at UNIFOR M. Behbahani: Numerical Analysis of Blood Pumps (Análise numérica de bombas de coração), November 06, 2007, University of Fortaleza (UNIFOR), Fortaleza Brasil, 2007.
ISRBP M. Behbahani: Modeling and Simulation of Blood Flow in LVADs, AICES/CCES Workshop on Blood Modeling: From Cell to Network, Aachen, September 20-21, 2007.
VRCA M. Behbahani, M. Nicolai: Interaktive Exploration von Blutströmungsprozessen in Herzpumpen, Virtual Reality Center, Aachen, November 21, 2006, abstract.
ISRBP M. Behbahani, M. Behr, D. Arora, O. Coronado, M. Pasquali: CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction , 14th. Congress of the International Society for Rotary Blood Pumps, Leuwen, Belgium, August 31-September 2, 2006, abstract.
ISRBP D. Arora, M. Behbahani, A. Lammel, B. Benkowski, R. White, F. Hussain, M. Behr, M. Pasquali: Computational Fluid Dynamics Analysis of MicroMed Debakey Pump , ASAIO Congress, June 8-10, 2006, abstract appeared in The Journal of the American Society of Artificial Organs, Vol 52, No.2, p.32A, 2006.

Posters

ASAIO-2010 conference in Baltimore, USA, poster platelets poster (pdf 10 MB)
This poster received a price: We could win the ASAIO Fellowship Award for it.

ASAIO-2010 conference in Baltimore, USA, poster aortic flow poster (pdf 15 MB)

ASAIO-2010 conference in Baltimore, USA, poster hemolysis poster (pdf 5 MB)

Biomedica-2010 congress in Aachen, Germany poster (pdf 13.4 MB)

NIC-2010 symposium 2010 in Jülich, Germany poster (pdf 16.7 MB)

Umbrella-2010 symposium in Jülich, Germany poster (pdf 15.6 MB)

ESB-2009 conference in Lausanne, Switzerland poster (pdf 16.5 MB)

FDA-2008 round-robin study poster (pdf 1.2 MB)

ESAO-2008 conference in Geneva, Switzerland poster (pdf 7.5 MB)

AICES-2007 blood modeling seminar poster (pdf 6.7 MB)

Publications

ISRBP B.M. Doorschodt, M-C. Schreinemachers, M. Behbahani, S. Florquine, J. Weis, M. Staat and R. Tolba: Hypothermic machine perfusion of kidney graft: which pressure is preferred?, Annals of Biomedical Engineering, vol. 39, number 3, pages 1051-1059, 2010, abstract.
ISRBP T. Finocchiaro, S. Heinke, M. Behbahani, M. Lessmann, M. Laumen, U. Steinseifer, T. Schmitz-Rode, S. Leonhardt, M. Behr and K. Hameyer: Methods of Design, Simulation, and Control for the Development of New VAD/TAH Concepts, Biomedizinische Technik/Biomedical Engineering, vol.54, issue 5, p269-282, 2009, abstract
ISRBP J. Spillner, R. Kopp, T. Finocchiaro, M. Behbahani, R. Roissaint, U. Steinseifer, M. Behr and R. Autschbach: Assistierte Zirkulation: ein Überblick aus klinischer Sicht, Biomedizinische Technik/Biomedical Engineering, vol.54, issue 5, p.255-268, 2009, abstract.
EJAM M. Behbahani, M. Behr, D. Arora, O. Coronado and M. Pasquali: A Review of Computational Fluid Dynamics Analysis of Blood Pumps, European Journal of Applied Mathematics, vol.20, p.363–397, 2009, abstract
NIC-report M. Behbahani, M. Behr, M. Nicolai,M. Probst: Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM, NIC(John von Neumann Institute for Computing)-report, Vol.39, p.325-332, 2008
EJAM M. Behbahani, M. Nicolai, M. Probst, M. Behr: Simulation of Blood Flow in a Ventricular Assist Device, inSIDE Spring 2007, Vol.5, No.1, p.28-31
RWTH_Themen M. Behbahani, M. Behr, C. Bischof, F.G.E. Wolf: Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe, RWTH Themen 01/07, p.44-46, 2007
JNNFM M. Behbahani, M. Nicolai: Interaktive Exploration von Blutströmungsprozessen in Herzpumpen, VRCA Jahresbericht 2005/2006, link to full report , Aachen, p.88-90, October 2006

Presentations

Numerical Modeling and Experimental Analysis of Platelet Reactions, AICES Aachen, 04/11
Vortrag zur Biomechanik des menschlichen Bewegungsapparates, RWTH Aachen, 03/11
Numerical and experimental study of platelet reactions in blood vessels, Klinikum Aachen, 09/10
The influence of high shear on thrombosis and hemolysis in artificial organs, ESAO, Skopje, Macedonia, 09/10
Validation of CFD with PIV and other methods, Part II, yESAO, Skopje, Macedonia, 09/10
3D Stereo-PIV Validation for CFD Simulation of Steady Flow Through the Human Aorta Using Rapid-Prototyping Techniques, MPF (Modeling of Physiological Flows), Sardinia, Italy, 07/10
Rheologie von Körpergewebe (Knorpel und Muskeln). FH Aachen, 06/10
An experimental study of platelet binding mechanisms in connection with the adhesive protein Von Willebrand factor. FH Aachen, 06/10
Bioengineering Lecture on blood flow and blood damage in biomedical devices. University Hospital, Aachen, 03/10
Modeling and simulation of flow-related thrombus formation under physiological and non-physiological flow conditions. Copenhagen, Denmark, 03/10
New Computational Method in Hemolysis Anlysis for Artificial Heart Pump. XVIth. International Workshop on Numerical Methods for Non-Newtonian Flows, Northhampton, USA, 06/10

Simulation of the Beating Human Heart, JARASIM. Steps 1-3: Human Aorta, coronary artery, left ventricle. Helmholtz-Institute, Aachen, 02/10
A Study of Platelet Adhesion Mechanisms inside the Taylor-Couette System, AME Tissue Engineering Aachen, 11/09
Numerical Blood Flow Analysis, Thrombosis Simulation and Experimental Validation, AICES Aachen, 11/09
Flow-related Thrombocyte Reactions: an Experimental and Numerical Study, Klinikum Aachen, 11/09
Simulation of Blood Damage in Technical Devices: Experiment, Modeling, and Numerical Simulation, FH Aachen, Jülich, 10/09
Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices, Compiegne University, France, 09/09
Simulation of the Beating Human Heart, JARASIM. First step: Human Aorta. Helmholtz-Institute, Aachen, 07/09
Flowchamber Experiments, Physiology, Aachen, 06/09
Taylor-Couette Simulation, CATS, Aachen, 12/07
Simulations and VR at Unifor, Fortaleza, Brazil, 11/07
Thrombosis, CATS, Aachen, 08/07
Debakey Mesh, CATS, Aachen, 08/07
Debakey Pump, ISRBP Leuven, Belgium, 09/06
Gyro Pump and SSMUM, Rice University, Texas, USA, 05/06

Simulation pictures

ISRBP Hemolyzing red blood cell in Micromed DeBakey axial blood pump. The mesh creation included the generation of an SSMUM (shear slip mesh update method) layer.
ISRBP Taylor-vortices forming in a cylindrical gap flow. Flow simulation results in good agreement with experiments performed in collaboration with the Aachen University ECC Physiology Group headed by Prof. Mottaghy. The influence of Taylor-vortices on the behavior of platelets was experimentally examined in Sabine Körfer's PhD thesis.
ISRBP shear stress distribution for turbulent flow through a Sudden Expansion at Re=6500
ISRBP axial velocity distribution for turbulent flow through a Sudden Expansion at Re=6500

ISRBP scanning electron microscopy picture of platelets and other blood cells adhering to the wall of a plastic channel. The strong adhesion and aggregation behavior was caused by activation with ADP.

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